Leading the Way in Life Science Technologies

GEN Exclusives

More »

Best of the Web

More »
Jun 15, 2011 (Vol. 31, No. 12)


  • Large database, nice sequence alignments and phylogenetic trees
  • Very brief annotations

So which came first, the chicken or the egg…nog? While this enigma may continue to plague humanity, at least there are a number of evolution-related questions that are more answerable. For instance, how have ancestral genes evolved in different species? What do these orthologous genes look like? Enter eggNOG (evolutionary genealogy of genes: Non-supervised Orthologous Groups), which is a database of orthologous groups of genes. Just how many groups, you ask? The database contains a whopping 224,847 groups that cover 630 species. One can either search by gene name or enter up to 30 protein sequences to retrieve the query results. These results include a phylogenetic tree showing the evolution of the protein of interest, as well as brief annotations for the orthologous genes. Also, as a website dedicated to the relationships between genes, the sequence alignment and tree-viewing options are a nice touch.

  • Key:
  • Strong Points
  • Weak Points
  • Ratings:
  • Excellent
  • Very Good
  • Good

*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

Be sure to take the GEN Poll

CRISPR Patent Controversy

Do you think recently released email from a former Broad Institute scientist to Jennifer Doudna will expedite a final legal decision on who owns the CRISPR patent?

More »