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Feb 01, 2011 (Vol. 31, No. 3)

Cytochrome P450 Homepage

  • Diverse collection of resources, site updated often
  • Site layout is a bit unpolished

As you know, the liver does much more than cope with the alcoholic aftermath of the Friday afternoon happy hour at your lab. The members of the cytochrome P450 superfamily of enzymes, the “worker bees” of the liver, are hard at work oxidizing xenobiotic substances and metabolic intermediates. A great resource to explore the vastness of this superfamily is provided by David Nelson of the University of Tennessee Health Science Center. His “Cytochrome P450 Homepage” provides pages upon pages of P450 information for a number of species, along with phylogenetic trees, 3-D structures, nomenclature resources, and plenty of additional links. Although the website isn’t the most polished in appearance, Dr. Nelson has certainly compiled enough resources to make this a true “home base” for researchers in search of P450 information.

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*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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