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Dec 01, 2005 (Vol. 25, No. 21)

CREB Target Gene Database

URL:natural.salk.edu/CREB/
  • Useful info
  • Better explanation needed
Before I review any site in this column, I search my database of previous reviews. I was surprised to discover that not only had I not previously reviewed this site, but also that I had only covered sites from the Salk Institute on two occasions in the nine years I've done the column. Hmmm. Makes me wonder about some gems there I may have missed. To the matter at hand, CREB is the Cyclic AMP (cAMP) Response Element Binding Protein family of factors involved in control of metabolism, response to growth factors, and other cellular responses. CREB can bind upwards of 5000 human promoter sequences, and can be activated not only by cAMP, but also by calcium, stress, and factors that stimulate mitosis. The database focuses on CREB target genes with information on binding sites, promoter occupancy, and gene activation by cAMP. While the information is extensive and useful, interpretation of the value of returned information is confusing, especially in view of the unclear descriptions.
  • Key:
  • Strong Points
  • Weak Points
  • Ratings:
  • Excellent
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  • Good


*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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