Systems Biology Opens New Research Pathways
Systems Biologists Are Attacking the Encrypted Messages That Would Allow Us to Predict and Change the Course of Disease
Individual Tumor Profiling
Has Tumor Molecular Profiling Enabled More Effective and Less Toxic Cancer Treatment?
Top 10 Under 40
Up-and-Coming Stars Shine in Biopharma Research and Business
Podcast: FDA’s New Commissioner Hits the Ground Running
Scott Gottlieb, M.D., Commits to Speeding Up Drug Reviews, and Maintaining Safety and Efficacy
Proteins are subject to modulation by ligands that bind to sites other than the protein’s active site. Many of these so-called allosteric modulators, as well as their protein targets, are catalogued in the Allosteric Database at Shanghai Jiao Tong University. The database contains approximately 8,000 modulator entries, and can be browsed by modulator, target, or index. The modulator browse page is nice in that it provides the 2D structure of each modulator and also denotes whether the modulator is an activator/inhibitor, endogenous, and “druggable”. One annoying limitation to the page is that the actual names of the modulators are not displayed. For that, one must proceed to the pages for individual compounds. There is also the option to search the database, if users have specific compounds/proteins in mind.