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Jun 15, 2011 (Vol. 31, No. 12)

3DID–3D Interacting Domains

URL:3did.irbbarcelona.org
  • Nice interface with 3-D structures, many ways to search
  • One tab (InterPreTS) not functional

DID you know that you can easily explore protein domain-domain and domain-motif interactions in all of their 3-D glory? That’s right, you can take your investigation to another dimension with 3DID, a database that combines protein domain interaction data with high-resolution 3-D protein structures. The website allows users to search by domain name, motif name, Pfam access code, or FASTA sequence and view interactions for the protein of interest via a freely rotatable Jmol structure. One can also browse the database. Conveniently, the top ten domains/motifs with the “most distinct interaction partners” are also displayed. (Any guess for the number one domain? Yep, that’s right: V-set. Obviously…) Finally, there is also a third option for exploring the database: one can search for direct interactions or paths between domains or motifs. These folks seem to have thought of everything!

  • Key:
  • Strong Points
  • Weak Points
  • Ratings:
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  • Good


*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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