Systems Biology Opens New Research Pathways
Systems Biologists Are Attacking the Encrypted Messages That Would Allow Us to Predict and Change the Course of Disease
Individual Tumor Profiling
Has Tumor Molecular Profiling Enabled More Effective and Less Toxic Cancer Treatment?
Top 10 Under 40
Up-and-Coming Stars Shine in Biopharma Research and Business
Podcast: FDA’s New Commissioner Hits the Ground Running
Scott Gottlieb, M.D., Commits to Speeding Up Drug Reviews, and Maintaining Safety and Efficacy
3DID–3D Interacting Domains
DID you know that you can easily explore protein domain-domain and domain-motif interactions in all of their 3-D glory? That’s right, you can take your investigation to another dimension with 3DID, a database that combines protein domain interaction data with high-resolution 3-D protein structures. The website allows users to search by domain name, motif name, Pfam access code, or FASTA sequence and view interactions for the protein of interest via a freely rotatable Jmol structure. One can also browse the database. Conveniently, the top ten domains/motifs with the “most distinct interaction partners” are also displayed. (Any guess for the number one domain? Yep, that’s right: V-set. Obviously…) Finally, there is also a third option for exploring the database: one can search for direct interactions or paths between domains or motifs. These folks seem to have thought of everything!