Assay Development

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• Synthetic Degrons Play The N-End Game
  The Boc₃Arg moiety may provide a general strategy to construct inhibitors that induce targeted protein degradation.
• Inhibitors That Put A Kink in Abl's Helix
  Researchers develop a direct-binding assay that enables the detection of allosteric inhibitors, which can suppress a cellular enzyme that contributes to leukemia.
• LAVAgel for Protein Diagnostics
  Researchers introduce a microfluidic, single-channel, multistage immunoblotting strategy toward scalable protein isoform analysis.
• Biographies for Compounds
  Researchers demonstrate the value of a tool that compares compounds solely on the basis of their bioactivity for virtual screening.
• Olympic Anti-Doping Goes for Gold
  Mass spec and imaging are among the tools antidrug testers use to catch up with the cheaters.
• Reducing Endocytosis Assay
  Researchers describe a new method of studying the endocytosis and recycling of cell surface proteins.
• New Luciferins
  Researchers describe a rapid method to synthesize D-luciferin along with a novel set of electronically modified analogues.
• Know Your Enzyme Forms
  Study demonstrates using an uncompetitive inhibitor as a probe to monitor the conformational change induced by compound binding with an HTRF assay.
• Secrecy Surrounds the Development of Tests to Detect Doping
  Therapeutic firms stress the need for a proactive approach against athletes who misuse drugs.

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