Autologous CAR-T Cell Manufacturing: Current Standing and Future Directions
A Look at What Drug Manufacturers are Likely Using to Make CAR-T Products
Supplement: MilliporeSigma Sees Opportunity in Continuous Processing
From the GEN Sounds of Science Podcast
Why CAR-T Therapies Don’t Work for Everyone Yet
Selecting the Best Type of T Cells for CAR-T May be Key to the Overall Efficacy of the Therapies
Cell-Centered: Scientists Embrace Cell-Replacement Therapy for Type 1 Diabetes
Forming Beta Cells from Stem Cells
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A Cellulose-Based Alkaline-Resistant Affinity Chromatography Resin Designed for the Industrial-Scale Purification of Monoclonal Antibodies
Therapeutic antibodies represent an innovative class of drugs used to treat a wide range of diseases such as rheumatoid arthritis and cancer Protein A chromatography resin is widely used in the production of therapeutic antibodies due to its high affinity and excellent selectivity for antibodies Utilizing our expertise in protein design and genetic engineering, we have made significant improvements to ‘Wild type’ or “Native’ Protein A ligand Immobilization of our improved Protein A ligand to highly cross-linked cellulose beads allows KANEKA KanCapA to exhibit alkaline resistance, stability over repeated cycle use, and to be used at high flow rates from laboratory to industrial scale with high binding capacity KanCapA exhibits excellent process development options, narrow pH elution for all monoclonal antibodies and non-binding Fab properties Mild pH elution avoids the formation of product aggregates Data presented here compares Kaneka KanCapA with already marketed PA resins and demonstrate the extremely high potential of KanCapA as the new PA , mAb purification platform...
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