Leading the Way in Life Science Technologies

GEN Exclusives

More »

Application Notes

More »

For full access to this article login to GEN Select now.

March 21, 2013

Kaneka Corporation

A Cellulose-Based Alkaline-Resistant Affinity Chromatography Resin Designed for the Industrial-Scale Purification of Monoclonal Antibodies

Therapeutic antibodies represent an innovative class of drugs used to treat a wide range of diseases such as rheumatoid arthritis and cancer Protein A chromatography resin is widely used in the production of therapeutic antibodies due to its high affinity and excellent selectivity for antibodies Utilizing our expertise in protein design and genetic engineering, we have made significant improvements to ‘Wild type’ or “Native’ Protein A ligand Immobilization of our improved Protein A ligand to highly cross-linked cellulose beads allows KANEKA KanCapA to exhibit alkaline resistance, stability over repeated cycle use, and to be used at high flow rates from laboratory to industrial scale with high binding capacity KanCapA exhibits excellent process development options, narrow pH elution for all monoclonal antibodies and non-binding Fab properties Mild pH elution avoids the formation of product aggregates Data presented here compares Kaneka KanCapA with already marketed PA resins and demonstrate the extremely high potential of KanCapA as the new PA , mAb purification platform...

Not registered yet? Please fill out the form below and enjoy complimentary access to this and an exclusive collection of premium content and personalization features as a GEN Select insider. Learn More.

Get GEN Select Access Now

    • Do not put any letters or characters here if you are not a spy program.

Related content