GEN UPDATES: Personalized Medicine and Regenerative Medicine

GEN Updates are microsites composed of articles commissioned for publication by Genetic Engineering & Biotechnology News and of peer-reviewed scientific papers from journals published by Mary Ann Liebert, Inc. They are intended to provide in-depth information and coverage on cutting-edge technologies and trends that are transforming drug discovery and life science research. This microsite, brought to you by our partner Enterprise Florida, contains a selection of recent articles from Genetic Engineering & Biotechnology News and the Mary Ann Liebert journal Tissue Engineering Part B: Reviews and highlights advances in Personalized Medicine and Regenerative Medicine.

Genetic Engineering & Biotechnology News (white paper)
Defining the Future of Healthcare: Personalized Medicine and Tissue Regeneration at the Forefront
Vicki Glazer

The future of healthcare depends on an expanding knowledge base of basic biological science and human health and disease as well as the integration of scientific discovery and evidence-based medicine with advances in information technology. Two technology-driven components of the healthcare revolution are personalized medicine and regenerative medicine. These growth sectors offer the opportunity to address unmet medical needs and transform the healthcare industry by translating research discoveries into definitive point-of-care diagnostics and safer, more effective therapeutics. Full Article

Tissue Engineering Part B: Reviews
The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine
David L. Butler, Steven A. Goldstein, Robert E. Guldberg, X. Edward Guo, Roger Kamm, Cato T. Laurencin, Larry V. McIntire, Van C. Mow, Robert M. Nerem, Robert L. Sah, Louis J. Soslowsky, Robert L. Spilker, and Robert T. Tranquillo

Biomechanical factors profoundly influence processes of tissue growth, development, maintenance, degeneration, and repair. This paper details the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. Full Article

Tissue Engineering Part B: Reviews
The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine
George F. Muschler, Vivek P. Raut, Thomas E. Patterson, Joseph C. Wenke, and Jeffrey O. Hollinger

This article provides an overview of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue. It also identifies gaps in the availability of animal models. Full Article

Genetic Engineering & Biotechnology News
The Underappreciated Cost-Saving Potential of Personalized Medicine in Health Reform Debate
Harry Glorikian and Brian Clancy

From the headlines over the past few months, it appears that Washington is overlooking the value of personalized medicine in reducing healthcare costs. This article offers examples of cost-saving diagnostics and delves into the role of personalized medicine in healthcare reform. Full Article

Genetic Engineering & Biotechnology News
Stem Cell Technologies Boost Regenerative Medicine
James Netterwald, Ph.D.

The regenerative role of stem cells in the human body is the subject of intensive research aimed at producing the next generation of effective cell-based cures for various human diseases. Advancement of regenerative medicine is contingent upon developments in stem cell technologies, creating a symbiotic relationship that represents a current impetus for change in biomedical research. Full Article

Genetic Engineering & Biotechnology News
Personalized Medicine Realizing Its Promise
Edward Abrahams, Ph.D.

In the modern conception of personalized medicine, the tools provided to the physician are more precise, probing the very molecular makeup of each patient. As evidence of its benefits grows, revision of laws, policy, education, and clinical practices is needed. Full Article

Tissue Engineering Part B: Reviews
Translational Models for Musculoskeletal Tissue Engineering and Regenerative Medicine
Robert L. Sah and Anthony Ratcliffe

Although many models for musculoskeletal tissue engineering and regenerative medicine are available and serve well to answer various questions, this review discusses the substantial need for improved and standardized animal models. Additionally, animal models, especially large animal models, are critical to the preclinical step of translating research from bench to bedside. Full Article

 

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